Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 Mar 13;94(5):763-70.
doi: 10.1038/sj.bjc.6602980.

Spatial and space-time clustering of childhood acute leukaemia in France from 1990 to 2000: a nationwide study

S Bellec  1 , D Hémon, J Rudant, A Goubin, J Clavel
Affiliations

Spatial and space-time clustering of childhood acute leukaemia in France from 1990 to 2000: a nationwide study

S Bellec et al. Br J Cancer. .

Abstract

This study aimed to investigate the spatial and space-time distributions of cases of childhood acute leukaemia (CL) during 1990-2000 over the whole French territory. A global spatial heterogeneity and a spatial autocorrelation were first considered using the methods proposed by Potthoff and Whittinghill, Moran and Rogerson methods. The presence of space-time interaction between the places of residence and the dates of diagnosis was investigated with the Knox's test. Finally, the Kulldorff's statistic permitted to scan the whole territory in search for localised clusters. Two time periods were considered (1990-1994, 1995-2000). Overall, a statistically significant spatial heterogeneity of a very small magnitude was observed in the incidence of CL over 1990-1994, but neither over 1995-2000 nor over the whole time period. Moreover, a significant overdispersion of 5.5% was evidenced for 0-4 year children living in isolated areas with more than 50 inhabitants per km(2). Cases older than 10 years living in the same area at diagnosis also tended to cluster within 6 months.

PubMed Disclaimer

References

    1. Akhtar S, Carpenter TE, Ajmal F, Rozi S, Adil S (2005) Space-time clustering of childhood leukaemia cases in Karachi, Pakistan. J Epidemiol Community Health 59: 221–222 - PMC - PubMed
    1. Alexander FE (1991) Investigations of localised spatial clustering and extra-Poisson variation. In The geographical epidemiology of childhood leukaemia and non-Hodgkin lymphomas in Great Britain, 1966–83, Draper, G. (ed). Vol. 53, pp 69–76. London: Studies on Medical and population Subjects. HMSO
    1. Alexander FE, Boyle P (1996) Methods for Investigating Localized Clustering of Disease Vol. 135. IARC Scientific Publications - PubMed
    1. Alexander FE, Boyle P, Carli PM, Coebergh JW, Draper GJ, Ekbom A, Levi F, McKinney PA, McWhirter W, Michaelis J, Peris-Bonet R, Petridou E, Pompe-Kirn V, Plisko I, Pukkala E, Rahu M, Storm H, Terracini B, Vatten L, Wray N (1998) Spatial clustering of childhood leukaemia: summary results from the EUROCLUS project. Br J Cancer 77: 818–824 - PMC - PubMed
    1. Alexander FE, Boyle P, Carli PM, Coebergh JW, Ekbom A, Levi F, McKinney PA, McWhirter W, Michaelis J, Peris-Bonet R, Petridou E, Pompe-Kirn V, Plesko I, Pukkala E, Rahu M, Stiller CA, Storm H, Terracini B, Vatten L, Wray N (1999) Population density and childhood leukaemia: results of the EUROCLUS Study. Eur J Cancer 35: 439–444 - PubMed

Publication types