Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2006 Mar;32(3):421-7.
doi: 10.1007/s00134-005-0039-8. Epub 2006 Feb 15.

An evaluation of systemic inflammatory response syndrome signs in the Sepsis Occurrence In Acutely Ill Patients (SOAP) study

Charles L Sprung  1 , Yasser Sakr, Jean-Louis Vincent, Jean-Roger Le Gall, Konrad Reinhart, V Marco Ranieri, Herwig Gerlach, Jonathan Fielden, C B Groba, Didier Payen
Affiliations
Multicenter Study

An evaluation of systemic inflammatory response syndrome signs in the Sepsis Occurrence In Acutely Ill Patients (SOAP) study

Charles L Sprung et al. Intensive Care Med. 2006 Mar.

Abstract

Objective: To define the frequency and prognostic implications of SIRS criteria in critically ill patients hospitalized in European ICUs.

Design and setting: Cohort, multicentre, observational study of 198 ICUs in 24 European countries.

Patients and interventions: All 3,147 new adult admissions to participating ICUs between 1 and 15 May 2002 were included. Data were collected prospectively, with common SIRS criteria.

Results: During the ICU stay 93% of patients had at least two SIRS criteria [respiratory rate (82%), heart rate (80%)]. The frequency of having three or four SIRS criteria vs. two was higher in infected than non-infected patients (p < 0.01). In non-infected patients having more than two SIRS criteria was associated with a higher risk of subsequent development of severe sepsis (odds ratio 2.6, p < 0.01) and septic shock (odds ratio 3.7, p < 0.01). Organ system failure and mortality increased as the number of SIRS criteria increased.

Conclusions: Although common in the ICU, SIRS has prognostic importance in predicting infections, severity of disease, organ failure and outcome.

PubMed Disclaimer

References

    1. JAMA. 2002 Aug 21;288(7):862-71 - PubMed
    1. QJM. 1996 Jul;89(7):515-22 - PubMed
    1. Keio J Med. 1999 Mar;48(1):28-37 - PubMed
    1. Crit Care Med. 2001 Apr;29(4):880-6 - PubMed
    1. Crit Care Med. 1997 Feb;25(2):372-4 - PubMed

Publication types

LinkOut - more resources