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. 1991 Jun 17;284(1):82-6.
doi: 10.1016/0014-5793(91)80767-w.

Activation of Epstein-Barr virus promoters by a growth-factor and a glucocorticoid

C Schuster  1 , S Chasserot-Golaz, G Beck
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Free article

Activation of Epstein-Barr virus promoters by a growth-factor and a glucocorticoid

C Schuster et al. FEBS Lett. .
Free article

Abstract

Transforming growth factor-beta (TGF-beta) and a glucocorticosteroid, Dexamethasone (DXM), both cause transcriptional induction of Epstein-Barr virus (EBV) early antigens (EA) in Daudi lymphoma cells. The viral induction occurs through the viral promoter DR overlapping an origin of replication which is active during the lytic cycle. Each hormone requires specific regions on the DR promoter. Since these regions also mediate the action of two viral transcription factors, EB1 and R, it may be emphasized that EB1 and/or R are involved in the EA induction process by TGF-beta and by DXM.

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