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Comparative Study
. 1991 Jun 24;284(2):211-5.
doi: 10.1016/0014-5793(91)80687-x.

A novel gamma subunit of the GABAA receptor identified using the polymerase chain reaction

D Wilson-Shaw  1 , M Robinson, C Gambarana, R E Siegel, J M Sikela
Affiliations
Free article
Comparative Study

A novel gamma subunit of the GABAA receptor identified using the polymerase chain reaction

D Wilson-Shaw et al. FEBS Lett. .
Free article

Abstract

We have utilized a polymerase chain reaction (PCR) strategy to identify a novel subunit, gamma 3, of the GABAA receptor. The gamma 3 cDNA encodes a mature protein of 450 amino acids that contains structural features typically conserved among subunits of the GABAA receptor family. The gamma 3 subunit shares approximately 66% sequence identity with the gamma 2 subunit but only 38% and 29% with alpha 1 and beta 1 subunits, respectively. Localization of the gamma 3 mRNA indicates that it is widely distributed throughout the mouse brain in a pattern similar to that observed for mRNAs encoding the gamma 2 subunits.

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