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. 2006 Aug;60(8):991-9.
doi: 10.1038/sj.ejcn.1602410. Epub 2006 Feb 15.

Antioxidants, oxidative stress, and pulmonary function in individuals diagnosed with asthma or COPD

H M Ochs-Balcom  1 , B J B Grant, P Muti, C T Sempos, J L Freudenheim, R W Browne, S E McCann, M Trevisan, P A Cassano, L Iacoviello, H J Schünemann
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Antioxidants, oxidative stress, and pulmonary function in individuals diagnosed with asthma or COPD

H M Ochs-Balcom et al. Eur J Clin Nutr. 2006 Aug.

Abstract

Objective: The objective of this study was to investigate the association between antioxidant nutrients and markers of oxidative stress with pulmonary function in persons with chronic airflow limitation.

Design: Cross-sectional study exploring the association of antioxidant nutrients and markers of oxidative stress with forced expiratory volume in the first second (FEV1%) and forced vital capacity (FVC%).

Setting/subjects: The study data included 218 persons with chronic airflow limitation recruited randomly from the general population of Erie and Niagara counties, New York State, USA.

Results: After adjustment for covariates, multiple linear regression analysis showed that serum beta-cryptoxanthin, lutein/zeaxanthin, and retinol, and dietary beta-carotene, beta-cryptoxanthin, lutein/zeaxanthin, vitamin C, and lycopene were positively associated with FEV1% (P < 0.05, all associations). Serum vitamins beta-cryptoxanthin, lutein/zeaxanthin, and lycopene, and dietary beta-cryptoxanthin, beta-carotene, vitamin C, and lutein/zeaxanthin were positively associated with FVC% (P < 0.05, all associations). Erythrocytic glutathione was negatively associated with FEV1%, while plasma thiobarbituric acid-reactive substances (TBARS) were negatively associated with FVC% (P < 0.05).

Conclusion: These results support the hypothesis that an imbalance in antioxidant/oxidant status is associated with chronic airflow limitation, and that dietary habits and/or oxidative stress play contributing roles.

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