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Review
. 2006 Mar;7(3):225-30.
doi: 10.1038/nrm1861.

A visual approach to proteomics

Stephan Nickell  1 , Christine Kofler, Andrew P Leis, Wolfgang Baumeister
Affiliations
Review

A visual approach to proteomics

Stephan Nickell et al. Nat Rev Mol Cell Biol. 2006 Mar.

Abstract

Cryo-electron tomography is an emerging imaging technique that has unique potential for molecular cell biology. At the present resolution of 4-5 nm, large supramolecular structures can be studied in unperturbed cellular environments and, in the future, it will become possible to map molecular landscapes inside cells in a more comprehensive manner. 'Visual proteomics' aims to complement and extend mass-spectrometry-based inventories, and to provide a quantitative description of the macromolecular interactions that underlie cellular functions.

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