doi: 10.1016/j.bmcl.2006.01.067.
Epub 2006 Feb 17.
Isoquinoline derivatives as potential acetylcholinesterase inhibitors
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- PMID: 16483771
- DOI: 10.1016/j.bmcl.2006.01.067
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Isoquinoline derivatives as potential acetylcholinesterase inhibitors
Bioorg Med Chem Lett.
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Abstract
Several bisbenzylisoquinoline alkaloid derivatives showed the inhibitory activity at acetylcholinesterase enzyme (AChE) in micromolar range. It is possible that monomeric moiety of bisbenzylisoquinoline alkaloid might be required for acetylcholinesterase enzyme inhibition. AChE inhibitory activity of related monomeric 1-benzylisoquinolines was examined by using Ellman colorimetric assay with galanthamine as a reference standard.
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