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. 2006 Apr 15;16(8):2170-2.
doi: 10.1016/j.bmcl.2006.01.067. Epub 2006 Feb 17.

Isoquinoline derivatives as potential acetylcholinesterase inhibitors

Sutthatip Markmee  1 , Somsak Ruchirawat, Vilailak Prachyawarakorn, Kornkanok Ingkaninan, Nantaka Khorana
Affiliations

Isoquinoline derivatives as potential acetylcholinesterase inhibitors

Sutthatip Markmee et al. Bioorg Med Chem Lett. .

Abstract

Several bisbenzylisoquinoline alkaloid derivatives showed the inhibitory activity at acetylcholinesterase enzyme (AChE) in micromolar range. It is possible that monomeric moiety of bisbenzylisoquinoline alkaloid might be required for acetylcholinesterase enzyme inhibition. AChE inhibitory activity of related monomeric 1-benzylisoquinolines was examined by using Ellman colorimetric assay with galanthamine as a reference standard.

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