Comment
doi: 10.1016/j.molcel.2006.02.002.
The odyssey of k-ras
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- PMID: 16483924
- DOI: 10.1016/j.molcel.2006.02.002
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Comment
The odyssey of k-ras
Mol Cell.
.
Free article
Abstract
A mechanism that regulates K-Ras signaling specificity by altering its subcellular location is presented by Bivona et al. (2006). Phosphorylation of its membrane-anchoring domain by PKC drives K-Ras off of the plasma membrane and onto the outer mitochondrial membrane where it induces cell death.
Comment on
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PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis.Mol Cell. 2006 Feb 17;21(4):481-93. doi: 10.1016/j.molcel.2006.01.012. Mol Cell. 2006. PMID: 16483930
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