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Comparative Study
. 1977 Apr;22(4):371-8.
doi: 10.1007/BF01072196.

Effects of parenteral secretin--cholecystokinin and of duodenal acid perfusion on gastric secretion in duodenal ulcer patients

J Butt, T Yoshida, B Fleshler
Comparative Study

Effects of parenteral secretin--cholecystokinin and of duodenal acid perfusion on gastric secretion in duodenal ulcer patients

J Butt et al. Am J Dig Dis. 1977 Apr.

Abstract

The effect of parenteral secretin-cholecystokinin and duodenal acid perfusion on broth-stimulated gastric acid secretion was studied in 11 duodenal ulcer patients. Statistically significant inhibition occurred in both experimental conditions. The effect of secretin-cholecystokinin was more marked than the effect of duodenal acid perfusion. A poorly responsive subgroup of patients appeared to be responsible for the diminished inhibitory effect of duodenal acid perfusion. In this poorly responsive group there was a diminished duodenal volume response as well as diminished duodenal acid clearing. We conclude that there may exist a diminished release of gastrointestinal hormones such as secretin and cholecystokinin in certain duodenal ulcer patients.

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References

    1. Gut. 1974 Nov;15(11):889-97 - PubMed
    1. Gut. 1964 Jun;5:237-40 - PubMed
    1. Gastroenterology. 1970 Jul;59(1):114-9 - PubMed
    1. Scand J Gastroenterol. 1970;5(3):207-15 - PubMed
    1. Gut. 1964 Dec;5:573-80 - PubMed

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