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Comparative Study
. 2006;21(5-6):291-5.
doi: 10.1159/000091436. Epub 2006 Feb 10.

The neurofilament heavy chain (NfH) in the cerebrospinal fluid diagnosis of Alzheimer's disease

Johannes Brettschneider  1 , Axel Petzold, Daniel Schottle, Annett Claus, Matthias Riepe, Hayrettin Tumani
Affiliations
Comparative Study

The neurofilament heavy chain (NfH) in the cerebrospinal fluid diagnosis of Alzheimer's disease

Johannes Brettschneider et al. Dement Geriatr Cogn Disord. 2006.

Abstract

Background/aims: Attempting to improve the cerebrospinal fluid (CSF) diagnosis of Alzheimer's disease (AD), the neurofilament heavy chain isoform, NfH(SMI35) was compared to other CSF markers [total tau, phospho-tau, amyloid beta 1-42 (Abeta42), the ratio of amyloid beta fragments Abeta42/Abeta40 (Abeta ratio)].

Methods: CSF levels were determined in patients with AD (n = 109), mild cognitive impairment (MCI, n = 25), frontotemporal dementia (n = 15), vascular dementia (VD, n = 41), and controls (n = 58).

Results: CSF NfH(SMI35) was elevated in AD and VD as compared to controls (p < 0.05). Total tau was higher in AD as compared to controls (p < 0.05). CSF phospho-tau was elevated in AD as compared to controls and VD (p < 0.05 each). CSF Abeta42 and Abeta ratios in AD were lower than in MCI and controls (p < 0.05 each).

Conclusion: The diagnostic potential of NfH(SMI35) is not superior to that of other CSF markers.

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