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. 1991 Mar;21(3):207-11.
doi: 10.1016/0165-0327(91)90041-p.

Effects of the antidepressant phenelzine on brain levels of gamma-aminobutyric acid (GABA)

G B Baker  1 , J T Wong, J M Yeung, R T Coutts
Affiliations

Effects of the antidepressant phenelzine on brain levels of gamma-aminobutyric acid (GABA)

G B Baker et al. J Affect Disord. 1991 Mar.

Abstract

Time- and dose-response studies were carried out on the effects of the monoamine oxidase-inhibiting antidepressant and antipanic drug phenelzine on GABA levels in rat whole brain. At a dose of 15 mg/kg i.p., phenelzine significantly elevated GABA levels at all time intervals studied (1, 2, 4, 8, 16, and 24 h). A further investigation indicated that this was a dose-dependent effect. The possible importance of GABA in the etiology and pharmacotherapy of depression and panic disorder is discussed.

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