Evidence that histamine H3 receptors are involved in the control of gastric acid secretion in the conscious cat
- PMID: 1648675
- DOI: 10.1007/BF00168615
Evidence that histamine H3 receptors are involved in the control of gastric acid secretion in the conscious cat
Abstract
In an attempt to assess the role of histamine H3 receptors in the control of gastric acid secretion, the effects of the selective histamine H3 receptor agonist, (R) alpha-methylhistamine and antagonist, thioperamide were evaluated in the conscious gastric fistula cat under basal conditions and against different stimuli. (R) alpha-methylhistamine (0.05-0.2 mumol/kg/h) was ineffective against spontaneous and dimaprit-induced acid secretion; it also did not reduce significantly pentagastrin-induced acid output, but caused a dose-dependent (0.05-0.1 mumol/kg/h) and significant inhibition of the acid response to 2-deoxy-D-glucose. Thioperamide (0.02-0.04 mumol/kg/h) did not modify spontaneous acid secretion, whereas it evoked a significant enhancement of the acid response to submaximal doses (50 mg/kg i.v.) of 2-deoxy-D-glucose. Thioperamide completely reversed the inhibitory effect of (R) alpha-methylhistamine against 2-deoxy-D-glucose-induced secretion, while leaving unaffected the inhibition induced by somatostatin. These data suggest that histamine H3 receptors may be involved in the control of acid secretion stimulated by indirectly acting secretagogues.
Similar articles
-
Histamine H3 receptor-mediated inhibition of gastric acid secretion in conscious dogs.Naunyn Schmiedebergs Arch Pharmacol. 1993 Jan;347(1):61-5. doi: 10.1007/BF00168773. Naunyn Schmiedebergs Arch Pharmacol. 1993. PMID: 8383301
-
Pharmacological evidence for histamine H3 receptor in the control of gastric acid secretion in cats.Am J Physiol. 1991 Apr;260(4 Pt 1):G631-5. doi: 10.1152/ajpgi.1991.260.4.G631. Am J Physiol. 1991. PMID: 1850206
-
Regulation of gastric acid secretion by histamine H3 receptors in the dog: an investigation into the site of action.Naunyn Schmiedebergs Arch Pharmacol. 1994 Aug;350(2):218-23. doi: 10.1007/BF00241100. Naunyn Schmiedebergs Arch Pharmacol. 1994. PMID: 7990981
-
Role of histamine H3 receptors in the regulation of gastric functions.J Physiol Pharmacol. 2001 Dec;52(4 Pt 1):539-53. J Physiol Pharmacol. 2001. PMID: 11787757 Review.
-
Review article: the histamine H3-receptor: a novel prejunctional receptor regulating gastrointestinal function.Aliment Pharmacol Ther. 1991 Dec;5(6):585-91. doi: 10.1111/j.1365-2036.1991.tb00526.x. Aliment Pharmacol Ther. 1991. PMID: 1664249 Review.
Cited by
-
Autoregulation of enterochromaffin-like cell histamine secretion via the histamine 3 receptor subtype.Yale J Biol Med. 1996 Jan-Feb;69(1):9-19. Yale J Biol Med. 1996. PMID: 9041685 Free PMC article.
-
New molecular targets for treatment of peptic ulcer disease.Drugs. 2003;63(17):1785-97. doi: 10.2165/00003495-200363170-00002. Drugs. 2003. PMID: 12921485 Review.
-
The histamine H3 receptor agonist N alpha-methylhistamine produced by Helicobacter pylori does not alter somatostatin release from cultured rabbit fundic D-cells.Gut. 1998 Aug;43(2):176-81. doi: 10.1136/gut.43.2.176. Gut. 1998. PMID: 10189840 Free PMC article.
-
Pharmacological profile of new thioperamide derivatives at histamine peripheral H1-, H2-, H3-receptors in guinea-pig.Agents Actions. 1993 Mar;38(3-4):158-64. doi: 10.1007/BF01976206. Agents Actions. 1993. PMID: 8213342
-
The new potent and selective histamine H2 receptor agonist amthamine as a tool to study gastric secretion.Naunyn Schmiedebergs Arch Pharmacol. 1993 Jul;348(1):77-81. doi: 10.1007/BF00168540. Naunyn Schmiedebergs Arch Pharmacol. 1993. PMID: 8377843
References
MeSH terms
Substances
LinkOut - more resources
Miscellaneous