Review
doi: 10.1016/j.coph.2005.10.007.
Epub 2006 Feb 17.
Hydrogen sulphide--a novel mediator of inflammation?
Affiliations
- PMID: 16487749
- DOI: 10.1016/j.coph.2005.10.007
Item in Clipboard
Review
Hydrogen sulphide--a novel mediator of inflammation?
Curr Opin Pharmacol.
2006 Apr.
Abstract
Hydrogen sulphide (H2S) is a naturally occurring gas synthesized from cysteine. It exhibits vasodilator activity (most probably by opening vascular smooth muscle K(ATP) channels), influences leucocyte chemotaxis and promotes vascular smooth muscle cell apoptosis. Increased biosynthesis of H2S has been demonstrated in animal models of septic/endotoxic and haemorrhagic shock, pancreatitis and carrageenan-evoked hindpaw oedema in the rat. In each case, pharmacological inhibition of H2S biosynthesis is anti-inflammatory.
Similar articles
-
Hydrogen sulfide as a vasodilator.IUBMB Life. 2005 Sep;57(9):603-6. doi: 10.1080/15216540500217875. IUBMB Life. 2005. PMID: 16203678 Review.
-
Gaso-transmitter hydrogen sulphide: potential new target in pharmacotherapy.Indian J Exp Biol. 2010 Nov;48(11):1069-77. Indian J Exp Biol. 2010. PMID: 21117445 Review.
-
[Hydrogen sulfide (H2S), an endogenous gas with odor of rotten eggs might be a cardiovascular function regulator].Ann Cardiol Angeiol (Paris). 2008 Jun;57(3):136-8. doi: 10.1016/j.ancard.2008.02.014. Epub 2008 Jun 4. Ann Cardiol Angeiol (Paris). 2008. PMID: 18579114 Review. French.
-
Hydrogen sulphide and its therapeutic potential.Nat Rev Drug Discov. 2007 Nov;6(11):917-35. doi: 10.1038/nrd2425. Nat Rev Drug Discov. 2007. PMID: 17948022 Review.
-
Hydrogen sulphide in the hypothalamus causes an ATP-sensitive K+ channel-dependent decrease in blood pressure in freely moving rats.Neuroscience. 2008 Mar 3;152(1):169-77. doi: 10.1016/j.neuroscience.2007.12.008. Neuroscience. 2008. PMID: 18201837
Cited by
-
Current Perspective of Hydrogen Sulfide as a Novel Gaseous Modulator of Oxidative Stress in Glaucoma.Antioxidants (Basel). 2021 Apr 26;10(5):671. doi: 10.3390/antiox10050671. Antioxidants (Basel). 2021. PMID: 33925849 Free PMC article. Review.
-
The pathogenic role of cystathionine γ-lyase/hydrogen sulfide in streptozotocin-induced diabetes in mice.Am J Pathol. 2011 Aug;179(2):869-79. doi: 10.1016/j.ajpath.2011.04.028. Epub 2011 Jun 2. Am J Pathol. 2011. PMID: 21718679 Free PMC article.
-
From urgency to frequency: facts and controversies of TRPs in the lower urinary tract.Nat Rev Urol. 2011 Oct 4;8(11):617-30. doi: 10.1038/nrurol.2011.142. Nat Rev Urol. 2011. PMID: 21971315 Review.
-
H2S protects against fatal myelosuppression by promoting the generation of megakaryocytes/platelets.J Hematol Oncol. 2016 Feb 24;9:13. doi: 10.1186/s13045-016-0244-7. J Hematol Oncol. 2016. PMID: 26912146 Free PMC article.
-
Assessment of the effect of sodium hydrogen sulfide (hydrogen sulfide donor) on cisplatin-induced testicular toxicity in rats.Environ Sci Pollut Res Int. 2020 Mar;27(8):8119-8128. doi: 10.1007/s11356-019-07266-5. Epub 2020 Jan 3. Environ Sci Pollut Res Int. 2020. PMID: 31900777
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
