Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2006 Dec 8;244(2):172-5.
doi: 10.1016/j.canlet.2005.12.006. Epub 2006 Feb 20.

ARLTS1 variants and risk of colorectal cancer

Bernd Frank  1 , Kari Hemminki, Hermann Brenner, Michael Hoffmeister, Jenny Chang-Claude, Barbara Burwinkel
Affiliations
Comparative Study

ARLTS1 variants and risk of colorectal cancer

Bernd Frank et al. Cancer Lett. .

Abstract

The Cys148Arg and Trp149Stop variants in the tumour suppressor gene ARLTS1 predispose to familial breast cancer, suggesting that these variants might also contribute to colorectal carcinogenesis. As the first to evaluate the association between Cys148Arg and Trp149Stop and colorectal cancer (CRC) risk, we genotyped 611 cases with CRC (including 77 cases with a first-degree family history) and 539 controls recruited from the German DACHS study. No significant differences in the genotype frequencies of Cys148Arg and Trp149Stop were observed between cases and controls. However, we showed a non-significant increased risk of familial CRC for both variants (OR=1.40 and 1.45), indicating a possible role of ARLTS1 in familial CRC.

PubMed Disclaimer

Publication types

Substances

LinkOut - more resources