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. 2006 Mar;3(3):179-81.
doi: 10.1038/nmeth855.

Formation of human prostate tissue from embryonic stem cells

Renea A Taylor  1 , Prue A Cowin, Gerald R Cunha, Martin Pera, Alan O Trounson, John Pedersen, Gail P Risbridger
Affiliations

Formation of human prostate tissue from embryonic stem cells

Renea A Taylor et al. Nat Methods. 2006 Mar.

Abstract

Rodent models and immortalized or genetically modified cell lines are frequently used-but have limited utility-for studying human prostate development and maturation. Using rodent mesenchyme to establish reciprocal mesenchymal-epithelial cell interactions with human embryonic stem cells (hESCs), we generated human prostate tissue expressing prostate-specific antigen (PSA) within 8-12 weeks. This human prostate model shows species-conserved signalling mechanisms that could extend to integumental, gastrointestinal and genital tissues.

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