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. 2006 Jan 28;12(4):603-7.
doi: 10.3748/wjg.v12.i4.603.

Pilot study of postoperative adjuvant chemoradiation for advanced gastric cancer: adjuvant 5-FU/cisplatin and chemoradiation with capecitabine

Hyung-Sik Lee  1 , Youngmin Choi, Won-Joo Hur, Hyo-Jin Kim, Hyuk-Chan Kwon, Sung-Hyun Kim, Jae-Seok Kim, Jong-Hoon Lee, Ghap-Joong Jung, Min-Chan Kim
Affiliations

Pilot study of postoperative adjuvant chemoradiation for advanced gastric cancer: adjuvant 5-FU/cisplatin and chemoradiation with capecitabine

Hyung-Sik Lee et al. World J Gastroenterol. .

Abstract

Aim: To evaluate the efficacy and toxicity of postoperative chemoradiation using FP chemotherapy and oral capecitabine during radiation for advanced gastric cancer following curative resection.

Methods: Thirty-one patients who had underwent a potentially curative resection for Stage III and IV (M0) gastric cancer were enrolled. Therapy consists of one cycle of FP (continuous infusion of 5-FU 1000 mg/m(2) on d 1 to 5 and cisplatin 60 mg/m(2) on d 1) followed by 4500 cGy (180 cGy/d) with capecitabine (1650 mg/m(2) daily throughout radiotherapy). Four wk after completion of the radiotherapy, patients received three additional cycles of FP every three wk. The median follow-up duration was 22.2 mo.

Results: The 3-year disease free and overall survival in this study were 82.7% and 83.4%, respectively. Four patients (12.9%) showed relapse during follow-up. Eight patients did not complete all planned adjuvant therapy. Grade 3/4 toxicities included neutropenia in 50.2%, anemia in 12.9%, thrombocytopenia in 3.2% and nausea/vomiting in 3.2%. Neither grade 3/4 hand foot syndrome nor treatment related febrile neutropenia or death were observed.

Conclusion: These preliminary results suggest that this postoperative adjuvant chemoradiation regimen of FP before and after capecitabine and concurrent radiotherapy appears well tolerated and offers a comparable toxicity profile to the chemoradiation regimen utilized in INT-0116. This treatment modality allowed successful loco-regional control rate and 3-year overall survival.

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Figures

Figure 1
Figure 1
Schema for postoperative chemoradiation study. 1 FP Chemotherapy: 5-FU 1 000 mg/m2 continuous infusion on d 1-5, cisplatin 60 mg/m2 on d 1. 2 Chemoradiation: 4 500 cGy at 180 cGy/d with capecitabine 1 650 mg/m2 daily during the entire radiotherapy course.
Figure 2
Figure 2
Overall survival and disease free survival for 31 patients with advanced gastric cancer treated with surgery followed by chemoradiotherapy.
See this image and copyright information in PMC

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