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. 2006 Apr;134(2):315-22.
doi: 10.1017/S0950268805004978.

Epidemiology and outcome of sepsis in a tertiary-care hospital in a developing country

M D Tanriover  1 , G S Guven, D Sen, S Unal, O Uzun
Affiliations

Epidemiology and outcome of sepsis in a tertiary-care hospital in a developing country

M D Tanriover et al. Epidemiol Infect. 2006 Apr.

Abstract

Sepsis continues to have a substantial mortality and morbidity despite advances in the diagnosis and management of this condition. We retrospectively analysed hospital charts of patients diagnosed to have sepsis between January 2002 and June 2003. Demographic characteristics of patients, microbiological findings and predictors of survival were evaluated. Sixty-nine sepsis episodes that occurred in 63 patients were analysed. The most common underlying diseases were hypertension, malignancies and diabetes mellitus. Renal insufficiency, respiratory distress and disseminated intravascular coagulation developed in 52.2, 30.4 and 30.4% of the episodes respectively; 47.7% of the blood cultures yielded an organism. Gram-negative bacteria were the predominant microorganisms (65.9%). Fifty-five patients (87.3%) died. Mechanical ventilation and underlying renal disease were significant determinants of mortality. In conclusion, Gram-negative bacteria remain the major pathogens in sepsis. The mortality remains very high, and a change in the clinical approach to the septic patient should be employed to improve the outcome.

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Figures

Fig
Fig
Mortality rates in community-acquired (□); hospital-acquired ( formula image) and all (■) sepsis episodes.
See this image and copyright information in PMC

References

    1. Riedemann NC, Guo RF, Ward PA. The enigma of sepsis. J Clin Invest. 2003;112:460–467. - PMC - PubMed
    1. Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med. 2003;348:1546–1554. - PubMed
    1. Levy MM, Fink MP, Marshall JC et al. SCCM/ESICM/ACCP/ATS/SIS. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med. 2003;31:1250–1256. - PubMed
    1. Arpi M, Renneberg J, Andersen HK, Nielsen B, Larsen SO. Bacteremia at a Danish university hospital during a twenty-five-year period (1968–1992) Scand J Infect Dis. 1995;27:245–251. - PubMed
    1. Velasco E, Byington R, Martins CSA, Schirmer M, Dias LCM, Gonçalves VMSC. Bloodstream infection surveillance in a cancer centre: a prospective look at clinical microbiology aspects. Clin Microbiol Infect. 2004;10:542–549. - PubMed