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Review
. 2006 Feb;7(2):131-42.
doi: 10.1038/nrm1835.

Complex networks orchestrate epithelial-mesenchymal transitions

Jean Paul Thiery  1 , Jonathan P Sleeman
Affiliations
Review

Complex networks orchestrate epithelial-mesenchymal transitions

Jean Paul Thiery et al. Nat Rev Mol Cell Biol. 2006 Feb.

Abstract

Epithelial-mesenchymal transition is an indispensable mechanism during morphogenesis, as without mesenchymal cells, tissues and organs will never be formed. However, epithelial-cell plasticity, coupled to the transient or permanent formation of mesenchyme, goes far beyond the problem of cell-lineage segregation. Understanding how mesenchymal cells arise from an epithelial default status will also have a strong impact in unravelling the mechanisms that control fibrosis and cancer progression.

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