Review
doi: 10.1038/nrm1835.
Complex networks orchestrate epithelial-mesenchymal transitions
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- PMID: 16493418
- DOI: 10.1038/nrm1835
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Review
Complex networks orchestrate epithelial-mesenchymal transitions
Nat Rev Mol Cell Biol.
2006 Feb.
Abstract
Epithelial-mesenchymal transition is an indispensable mechanism during morphogenesis, as without mesenchymal cells, tissues and organs will never be formed. However, epithelial-cell plasticity, coupled to the transient or permanent formation of mesenchyme, goes far beyond the problem of cell-lineage segregation. Understanding how mesenchymal cells arise from an epithelial default status will also have a strong impact in unravelling the mechanisms that control fibrosis and cancer progression.
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