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. 2006 Mar 2;8(5):807-10.
doi: 10.1021/ol0527532.

Relationship between salt-bridge identity and 14-helix stability of beta3-peptides in aqueous buffer

Danielle A Guarracino  1 , Hyojin R Chiang, Tereece N Banks, James D Lear, Michael E Hodsdon, Alanna Schepartz
Affiliations

Relationship between salt-bridge identity and 14-helix stability of beta3-peptides in aqueous buffer

Danielle A Guarracino et al. Org Lett. .

Abstract

We report a systematic analysis of the relationship between salt bridge composition and 14-helix structure within a family of model beta-peptides in aqueous buffer. We find an inverse relationship between side-chain length and the extent of 14-helix structure as judged by CD. Introduction of a stabilizing salt bridge pair within a previously reported beta-peptide ligand for hDM2 led to changes in structure that were detectable by NMR.

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