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. 2006 Jan;12(1):147-50.
doi: 10.3201/eid1201.050772.

Novel human metapneumovirus sublineage

Barbara Huck  1 , Gesa Scharf, Dieter Neumann-Haefelin, Wolfram Puppe, Josef Weigl, Valeria Falcone
Affiliations

Novel human metapneumovirus sublineage

Barbara Huck et al. Emerg Infect Dis. 2006 Jan.

Abstract

In a pediatric surveillance network, 287 (5.1%) of 5,580 specimens from patients with acute respiratory infections tested positive for human metapneumovirus (HMPV). Phylogenetic analysis of N- and F-gene sequences of identified HMPV showed that 30% belonged to a novel phylogenetic cluster.

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Figures

Figure 1
Figure 1
eighbor-joining phylogenetic trees of human metapneumovirus (HMPV). A) Partial F gene (506-nucleotide [nt] fragment). B) Partial N gene (424-nt fragment) of 191 HMPV strains recovered in Germany during the 2003–2004 season. Bootstrap resampling was applied (n = 1,000) with random sequence addition. Bootstrap values based on the consensus tree are plotted at the main internal branches to show support values. Sequences from the avian metapneumovirus C were included in the analysis and used as outgroup. Isolates from the Netherlands, Japan, and Canada were additionally included in the analysis.
Figure 2
Figure 2
Circulation of human metapneumovirus (HMPV) in Germany in a 2-year period from October 2002 to June 2004. A) Distribution of HMPV genotypes of 39 patients tested during the 2002–2003 season and 191 patients tested during the 2003–2004 season. B) Seasonal distribution of HMPV-infected patients and overall study admissions by month of admission. Further information about other respiratory pathogens cocirculating during the observed season is available from http://www.pid-ari.net
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