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. 2006 Mar;50(3):1104-7.
doi: 10.1128/AAC.50.3.1104-1107.2006.

NorC, a new efflux pump regulated by MgrA of Staphylococcus aureus

Que Chi Truong-Bolduc  1 , Jacob Strahilevitz, David C Hooper
Affiliations

NorC, a new efflux pump regulated by MgrA of Staphylococcus aureus

Que Chi Truong-Bolduc et al. Antimicrob Agents Chemother. 2006 Mar.

Abstract

NorC, a new efflux pump, like NorB, contributes to quinolone resistance that includes resistance to moxifloxacin and sparfloxacin in Staphylococcus aureus. norC expression, like that of norB and tet38, is negatively regulated by MgrA, and overexpression of both norC and norB contributes to the quinolone resistance phenotype of an mgrA mutant.

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Figures

FIG. 1.
FIG. 1.
(A) Noncompetitive quantitative RT-PCR using ORF SA0098 RNA as standard RNA and norC mRNA as target RNA. The output signals of the two amplification products were plotted versus the amount of standard RNA. (B) Graphic representation of the quantitative RT-PCR. The target signal (norC amplicon) remains constant, and the standard curve (SA0098 amplicon) is linear. The intersection point between the two lines is the equivalence point and indicates the arbitrary value for the norC amplicons.
See this image and copyright information in PMC

References

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