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. 1991 Jul 4;58(3):183-7.
doi: 10.1016/0304-3835(91)90098-3.

Effects of alprazolam on T-cell immunosuppressive response to surgical stress in mice

M Freire-Garabal  1 , A Belmonte, F Orallo, J Couceiro, M J Núñez
Affiliations

Effects of alprazolam on T-cell immunosuppressive response to surgical stress in mice

M Freire-Garabal et al. Cancer Lett. .

Abstract

Mice submitted to surgical stress induced by laparotomy and treated with chronic alprazolam (1 mg/kg) showed a reduction in stress-induced suppression of thymus and spleen cellularity, as well as in peripheral T lymphocyte population. The blastic response of spleen lymphoid cells was also assessed and found to partially supress the inhibitory effect of surgery.

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