Review
doi: 10.1515/BC.2006.022.
Anti-inflammatory effects of kinins via microglia in the central nervous system
Affiliations
- PMID: 16497148
- DOI: 10.1515/BC.2006.022
Item in Clipboard
Review
Anti-inflammatory effects of kinins via microglia in the central nervous system
Biol Chem.
2006 Feb.
Abstract
Kinins are important biologically active peptides that are up-regulated after lesions in both the peripheral and central (CNS) nervous systems. Microglia are immune cells in the CNS and play an important role in the defense of the neuronal parenchyma. In cultured murine microglia, bradykinin (BK) induces mobilization of intracellular Ca2+, microglial migration, and increases the release of nitric oxide and prostaglandin E2. On the other hand, BK attenuates lipopolysaccharide-activated TNF-alpha and IL-1beta release. These results suggest that BK functions as a signal in brain trauma and may have an anti-inflammatory role in the CNS.
Similar articles
-
5-Chloroacetyl-2-amino-1,3-selenazoles attenuate microglial inflammatory responses through NF-kappaB inhibition.Eur J Pharmacol. 2008 Jul 28;589(1-3):53-7. doi: 10.1016/j.ejphar.2008.03.034. Epub 2008 Apr 1. Eur J Pharmacol. 2008. PMID: 18538761
-
Multifunctional effects of bradykinin on glial cells in relation to potential anti-inflammatory effects.Neurochem Int. 2007 Jul-Sep;51(2-4):185-91. doi: 10.1016/j.neuint.2007.06.017. Epub 2007 Jun 27. Neurochem Int. 2007. PMID: 17669557 Review.
-
IL-1beta, an immediate early protein secreted by activated microglia, induces iNOS/NO in C6 astrocytoma cells through p38 MAPK and NF-kappaB pathways.J Neurosci Res. 2006 Oct;84(5):1037-46. doi: 10.1002/jnr.21011. J Neurosci Res. 2006. PMID: 16881054
-
Anti-inflammatory effects of m-chlorophenylpiperazine in brain glia cells.Int Immunopharmacol. 2008 Dec 10;8(12):1686-94. doi: 10.1016/j.intimp.2008.08.004. Epub 2008 Sep 2. Int Immunopharmacol. 2008. PMID: 18771755
-
Kinin receptors in cultured rat microglia.Neurochem Int. 2004 Jul-Aug;45(2-3):437-42. doi: 10.1016/j.neuint.2003.07.007. Neurochem Int. 2004. PMID: 15145558 Review.
Cited by
-
Bradykinin-induced microglial migration mediated by B1-bradykinin receptors depends on Ca2+ influx via reverse-mode activity of the Na+/Ca2+ exchanger.J Neurosci. 2007 Nov 28;27(48):13065-73. doi: 10.1523/JNEUROSCI.3467-07.2007. J Neurosci. 2007. PMID: 18045900 Free PMC article.
-
Distinct modulation of microglial amyloid β phagocytosis and migration by neuropeptides (i).J Neuroinflammation. 2010 Oct 11;7:61. doi: 10.1186/1742-2094-7-61. J Neuroinflammation. 2010. PMID: 20937084 Free PMC article.
-
The changing phenotype of microglia from homeostasis to disease.Transl Neurodegener. 2012 Apr 24;1(1):9. doi: 10.1186/2047-9158-1-9. Transl Neurodegener. 2012. PMID: 23210447 Free PMC article.
-
Involvement of bradykinin in brain edema development after ischemic stroke.Pflugers Arch. 2015 Feb;467(2):201-12. doi: 10.1007/s00424-014-1519-x. Epub 2014 Apr 23. Pflugers Arch. 2015. PMID: 24756199 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous
