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. 2006 May 1;16(9):2364-8.
doi: 10.1016/j.bmcl.2006.01.124. Epub 2006 Feb 23.

RNA specific molecules: cytotoxic plant alkaloid palmatine binds strongly to poly(A)

Prabal Giri  1 , Maidul Hossain, Gopinatha Suresh Kumar
Affiliations

RNA specific molecules: cytotoxic plant alkaloid palmatine binds strongly to poly(A)

Prabal Giri et al. Bioorg Med Chem Lett. .

Abstract

The cytotoxic plant alkaloid palmatine was found to bind strongly by partial intercalation to single stranded poly(A) structure with binding affinity (Ka) of (8.36+/-0.26) x 10(5) M(-1). The binding of palmatine was characterized to be exothermic and enthalpy driven with one palmatine for every two adenine residues. On the other hand, the binding to the double stranded poly(A) has been found to be significantly weak. This study identifies poly(A) as a potential bio-target for the alkaloid palmatine and its use as a lead compound in antitumor drug screening.

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