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. 2006 Apr;59(4):424-8.
doi: 10.1136/jcp.2005.029264. Epub 2006 Feb 23.

c-myc amplifications in primary breast carcinomas and their local recurrences

S Aulmann  1 , N Adler, J Rom, B Helmchen, P Schirmacher, H P Sinn
Affiliations

c-myc amplifications in primary breast carcinomas and their local recurrences

S Aulmann et al. J Clin Pathol. 2006 Apr.

Abstract

Objective: To evaluate the role of c-myc oncogene amplifications in the progression of invasive breast carcinomas.

Methods: c-myc gene copy number was evaluated in a series of 49 primary breast carcinomas and the corresponding local recurrences using fluorescence in situ hybridisation.

Results: 11 of the primary carcinomas (22%) harboured c-myc amplifications; these tumours typically were hormone receptor negative and occurred in younger patients (43 v 53 years). At the time of relapse, six additional tumours had acquired a c-myc amplification. The mean recurrence-free survival was 24 months; c-myc amplified tumours relapsed significantly earlier than carcinomas without amplification (18 v 27 months). Univariate analysis showed a worse overall survival in these patients.

Conclusions: While c-myc amplifications can be observed in early stage breast cancer, especially in younger patients, they often occur later in tumour development and appear to be associated with disease progression.

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