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. 2006 Apr;37(4):1109-12.
doi: 10.1161/01.STR.0000206446.26702.e9. Epub 2006 Feb 23.

Brain stem and cerebellar hyperintense lesions in migraine

Mark C Kruit  1 , Lenore J Launer, Michel D Ferrari, Mark A van Buchem
Affiliations

Brain stem and cerebellar hyperintense lesions in migraine

Mark C Kruit et al. Stroke. 2006 Apr.

Abstract

Background and purpose: Migraineurs are at increased risk of cerebellar infarcts and supratentorial white matter lesions. The prevalence, frequency, and distribution of infratentorial hyperintense lesions in migraine are unknown.

Methods: Migraineurs with aura (n=161), without aura (n=134), and controls (n=140) from a population-based sample of adults (30 to 60 years of age) were evaluated with MRI.

Results: Infratentorial hyperintensities were identified in 13 of 295 (4.4%) migraineurs and in 1 of 140 (0.7%) controls (P=0.04). Twelve cases had hyperintensities, mostly bilaterally, in the dorsal basis pontis. Those with infratentorial hyperintensities also had supratentorial white matter lesions more often.

Conclusions: We found an increased prevalence of infratentorial (mostly pontine) hyperintensities in migraineurs from the general population. This extends the knowledge about vulnerable brain regions and type of lesions in migraine brains. A hemodynamic ischemic pathogenesis is likely, but further research is needed.

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