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Review
. 2006 Apr;10(2):169-76.
doi: 10.1016/j.cbpa.2006.02.006. Epub 2006 Feb 24.

Biocatalysis in pharmaceutical preparation and alteration

Barrie Wilkinson  1 , Brian O Bachmann
Affiliations
Review

Biocatalysis in pharmaceutical preparation and alteration

Barrie Wilkinson et al. Curr Opin Chem Biol. 2006 Apr.

Abstract

The term 'synthetic biology' is being used with increasing frequency to describe the biocatalytic generation of small molecules, either via stepwise biotransformation or engineered biosynthetic pathways. The flexibility of this newly coined term encompasses the historically separate fields of natural product biosynthesis and metabolic engineering. This review discusses the state of the art of these two disciplines in the context of the discovery and development of bioactive precursors and products.

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