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. 2006 Apr;38(4):411-3.
doi: 10.1038/ng1742. Epub 2006 Feb 26.

ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis

Matthew J Greenway  1 , Peter M Andersen, Carsten Russ, Sean Ennis, Susan Cashman, Colette Donaghy, Victor Patterson, Robert Swingler, Dairin Kieran, Jochen Prehn, Karen E Morrison, Andrew Green, K Ravi Acharya, Robert H Brown Jr, Orla Hardiman
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ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis

Matthew J Greenway et al. Nat Genet. 2006 Apr.

Abstract

We recently identified angiogenin (ANG) as a candidate susceptibility gene for amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder characterized by adult-onset loss of motor neurons. We now report the finding of seven missense mutations in 15 individuals, of whom four had familial ALS and 11 apparently 'sporadic' ALS. Our findings provide further evidence that variations in hypoxia-inducible genes have an important role in motor neuron degeneration.

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