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. 1991 Jul 15;277 ( Pt 2)(Pt 2):573-6.
doi: 10.1042/bj2770573.

Raf-1 is a potential substrate for mitogen-activated protein kinase in vivo

N G Anderson  1 , P Li, L A Marsden, N Williams, T M Roberts, T W Sturgill
Affiliations

Raf-1 is a potential substrate for mitogen-activated protein kinase in vivo

N G Anderson et al. Biochem J. .

Abstract

MAP (mitogen-activated protein) kinase is shown to phosphorylate baculovirally expressed Raf-1 in vitro, generating one major tryptic phosphopeptide which co-migrated with a peptide from Raf-1 32P-labelled in situ. This peptide also undergoes an insulin-dependent increase in labelling. Thus the serine/threonine kinase Raf-1 may be a substrate for MAP kinase in vivo.

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References

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