doi: 10.1016/0006-8993(91)91301-g.
The presence of CO2/HCO3- is essential for hypoxic chemotransduction in the in vivo perfused carotid body
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- PMID: 1650278
- DOI: 10.1016/0006-8993(91)91301-g
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The presence of CO2/HCO3- is essential for hypoxic chemotransduction in the in vivo perfused carotid body
Brain Res.
.
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Abstract
Carotid chemoreceptor activity was increased by the perfusion of the carotid body in vivo with hypoxic HEPES-buffered solution (HBS) containing CO2/HCO3- (HBA+), but not with hypoxic HBS without CO2/HCO3- (HBS-). When the perfusate was switched to hypoxic HBS+ during hypoxic HBS-perfusions, chemoreceptor activity increased immediately. Thus, CO2/HCO3- played a critical role in the hypoxic chemotransduction of the in vivo perfused carotid body.
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