Review
[Immune regulatory importance of prostaglandins E in atopy]
[Article in
German]
Affiliations
- PMID: 1650336
Item in Clipboard
Review
[Immune regulatory importance of prostaglandins E in atopy]
[Article in
German]
Hautarzt.
1991 Apr.
Abstract
The concept proposed for the pathogenesis and prevention of atopy [Hautarzt (1989) 40:685-692] is refined by further insights into the immunoregulatory role of E-prostaglandins. It is demonstrated that in vitro IgE synthesis of peripheral blood mononuclear cell cultures of patients with atopic dermatitis is suppressed by the addition of PGE1 or PGE2. The enhanced IgE production in atopy is explained by insufficient PGE-mediated down-regulation of interleukin-4-induced IgE synthesis.
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