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. 2006 Feb 21:4:4.
doi: 10.1186/1477-9560-4-4.

Recent acquisitions in the pathophysiology, diagnosis and treatment of disseminated intravascular coagulation

Massimo Franchini  1 , Giuseppe Lippi, Franco Manzato
Affiliations

Recent acquisitions in the pathophysiology, diagnosis and treatment of disseminated intravascular coagulation

Massimo Franchini et al. Thromb J. .

Abstract

Disseminated intravascular coagulation (DIC) is a disorder characterized by both acute generalized, widespread activation of coagulation, which results in thrombotic complications due to the intravascular formation of fibrin, and diffuse hemorrhages, due to the consumption of platelets and coagulation factors. Systemic activation of coagulation may occur in a variety of disorders, including sepsis, severe infections, malignancies, obstetric or vascular disorders, and severe toxic or immunological reactions. In this review, we briefly report the present knowledge about the pathophysiology and diagnosis of DIC. Particular attention is also given to the current standard and experimental therapies of overt DIC.

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Figures

Figure 1
Figure 1
Clinical manifestations of coagulation abnormalities in disseminated intravascular coagulation.
Figure 2
Figure 2
Five-step algorithm for the diagnosis of disseminated intravascular coagulation.
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