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. 1991 Mar 13;101(2):115-24.
doi: 10.1007/BF00229529.

Specific cleavage of chicken alpha A-globin and human c-Ha-ras genes by two molecular forms of calf thymus topoisomerase I

I B Bronstein  1 , I I Gromova, S V Razin
Affiliations

Specific cleavage of chicken alpha A-globin and human c-Ha-ras genes by two molecular forms of calf thymus topoisomerase I

I B Bronstein et al. Mol Cell Biochem. .

Abstract

Two molecular forms of topoisomerase I differing in size and sensitivity to camptothecin were isolated from calf thymus. Mapping of topo I cleavage sites of the cloned chicken alpha A-globin and human c-Ha-ras genes was carried out. Camptothecin was shown to affect site specificity of the topoisomerases.

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