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. 2006 Aug;30(8):979-86.
doi: 10.1016/j.leukres.2005.12.029. Epub 2006 Feb 28.

The NPM-RAR fusion protein associated with the t(5;17) variant of APL does not interact with PML

Elizabeth A Rush  1 , Kimberly W Schlesinger, Simon C Watkins, Robert L Redner
Affiliations

The NPM-RAR fusion protein associated with the t(5;17) variant of APL does not interact with PML

Elizabeth A Rush et al. Leuk Res. 2006 Aug.

Abstract

The PML protein localizes to regions of the nucleus known as nuclear bodies or PODs. However, in t(15;17) Acute Promyelocytic Leukemia (APL) blasts, PML is found in a micro-punctate pattern. In order to test the hypothesis that delocalization of PML from PODs is necessary for APL, we investigated the interaction of the t(5;17) APL fusion protein NPM-RAR with PML. NPM-RAR localizes diffusely throughout the nucleoplasm. NPM-RAR does not alter the localization of PML in transfected HeLa cells, and does not associate with PML in vitro. These studies suggest that NPM-RAR does not interact with PML.

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