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. 2006 Jun;22(3):691-3.
doi: 10.1016/j.nbd.2006.01.007. Epub 2006 Feb 28.

Association study of the Ubiquilin gene with Alzheimer's disease

Faiza Bensemain  1 , Julien Chapuis, Jinzhou Tian, Jing Shi, Uma Thaker, Corinne Lendon, Takeshi Iwatsubo, Philippe Amouyel, David Mann, Jean-Charles Lambert
Affiliations

Association study of the Ubiquilin gene with Alzheimer's disease

Faiza Bensemain et al. Neurobiol Dis. 2006 Jun.

Abstract

Recently, the ubiquilin 1 gene has been proposed as a major candidate gene for AD. Here, we have investigated the potential impact of the UBQ-8i polymorphism (rs12344615) within this gene on the risk of developing AD. No association of this polymorphism with the disease was observed in a large French case-control population. Furthermore, no relationship between this polymorphism and Abeta load or degree of neurofibrillary degeneration in the brains of 114 patients with AD was detected.

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