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. 2006 Mar;101(3):e37-44.
doi: 10.1016/j.tripleo.2005.07.008. Epub 2006 Jan 19.

Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution

David M Dohan  1 , Joseph Choukroun, Antoine Diss, Steve L Dohan, Anthony J J Dohan, Jaafar Mouhyi, Bruno Gogly
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Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution

David M Dohan et al. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Mar.

Abstract

Platelet-rich fibrin (PRF) belongs to a new generation of platelet concentrates geared to simplified preparation without biochemical blood handling. In this initial article, we describe the conceptual and technical evolution from fibrin glues to platelet concentrates. This retrospective analysis is necessary for the understanding of fibrin technologies and the evaluation of the biochemical properties of 3 generations of surgical additives, respectively fibrin adhesives, concentrated platelet-rich plasma (cPRP) and PRF. Indeed, the 3-dimensional fibrin architecture is deeply dependent on artificial clinical polymerization processes, such as massive bovine thrombin addition. Currently, the slow polymerization during PRF preparation seems to generate a fibrin network very similar to the natural one. Such a network leads to a more efficient cell migration and proliferation and thus cicatrization.

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Comment in

  • Safety issues associated with platelet-rich fibrin method.
    O'Connell SM. O'Connell SM. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 May;103(5):587; author reply 587-93. doi: 10.1016/j.tripleo.2007.03.017. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007. PMID: 17466883 No abstract available.

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