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. 2006 Mar;101(3):e45-50.
doi: 10.1016/j.tripleo.2005.07.009. Epub 2006 Jan 10.

Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet-related biologic features

David M Dohan  1 , Joseph Choukroun, Antoine Diss, Steve L Dohan, Anthony J J Dohan, Jaafar Mouhyi, Bruno Gogly
Affiliations

Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet-related biologic features

David M Dohan et al. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Mar.

Abstract

Platelet-rich fibrin (PRF) belongs to a new generation of platelet concentrates, with simplified processing and without biochemical blood handling. In this second article, we investigate the platelet-associated features of this biomaterial. During PRF processing by centrifugation, platelets are activated and their massive degranulation implies a very significant cytokine release. Concentrated platelet-rich plasma platelet cytokines have already been quantified in many technologic configurations. To carry out a comparative study, we therefore undertook to quantify PDGF-BB, TGFbeta-1, and IGF-I within PPP (platelet-poor plasma) supernatant and PRF clot exudate serum. These initial analyses revealed that slow fibrin polymerization during PRF processing leads to the intrinsic incorporation of platelet cytokines and glycanic chains in the fibrin meshes. This result would imply that PRF, unlike the other platelet concentrates, would be able to progressively release cytokines during fibrin matrix remodeling; such a mechanism might explain the clinically observed healing properties of PRF.

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Comment in

  • Safety issues associated with platelet-rich fibrin method.
    O'Connell SM. O'Connell SM. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 May;103(5):587; author reply 587-93. doi: 10.1016/j.tripleo.2007.03.017. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007. PMID: 17466883 No abstract available.

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