Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part III: leucocyte activation: a new feature for platelet concentrates?
- PMID: 16504851
- DOI: 10.1016/j.tripleo.2005.07.010
Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part III: leucocyte activation: a new feature for platelet concentrates?
Abstract
Platelet-rich fibrin (PRF) belongs to a new generation of platelet concentrates, with simplified processing and without biochemical blood handling. In this third article, we investigate the immune features of this biomaterial. During PRF processing, leucocytes could also secrete cytokines in reaction to the hemostatic and inflammatory phenomena artificially induced in the centrifuged tube. We therefore undertook to quantify 5 significant cell mediators within platelet poor plasma supernatant and PRF clot exudate serum: 3 proinflammatory cytokines (IL-1beta, IL-6, and TNF-alpha), an antiinflammatory cytokine (IL-4), and a key growth promoter of angiogenesis (VEGF). Our data are correlated with that obtained in plasma (nonactivated blood) and in sera (activated blood). These initial analyses revealed that PRF could be an immune regulation node with inflammation retrocontrol abilities. This concept could explain the reduction of postoperative infections when PRF is used as surgical additive.
Comment in
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Why the platelet-rich gel has antimicrobial activity?Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Mar;103(3):303-5; author reply 305-6. doi: 10.1016/j.tripleo.2006.08.034. Epub 2007 Jan 2. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007. PMID: 17197209 No abstract available.
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Safety issues associated with platelet-rich fibrin method.Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 May;103(5):587; author reply 587-93. doi: 10.1016/j.tripleo.2007.03.017. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007. PMID: 17466883 No abstract available.
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