Rookie snail protein LAPS veteran C/EBP: net transcriptional proceeds for long-term facilitation
- PMID: 16504938
- DOI: 10.1016/j.neuron.2006.02.009
Rookie snail protein LAPS veteran C/EBP: net transcriptional proceeds for long-term facilitation
Abstract
Long-term changes in synaptic plasticity require new protein synthesis. This preview discusses data from Kim et al. (this issues of Neuron) that demonstrate the requirement of a novel, nucleolar protein, LLP (LAPS18-like protein), for the formation of long-term facilitation in Aplysia. LLP binds to and transcriptionally activates C/EBP, thereby promoting the formation of long-term facilitation and behavioral sensitization.
Comment on
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A nucleolar protein ApLLP induces ApC/EBP expression required for long-term synaptic facilitation in aplysia neurons.Neuron. 2006 Mar 2;49(5):707-18. doi: 10.1016/j.neuron.2006.01.035. Neuron. 2006. PMID: 16504946
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