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Clinical Trial
. 2006 Feb 28;66(4):587-9.
doi: 10.1212/01.wnl.0000197792.73656.c2.

PCV chemotherapy for recurrent glioblastoma

F Schmidt  1 , J Fischer, U Herrlinger, K Dietz, J Dichgans, M Weller
Affiliations
Clinical Trial

PCV chemotherapy for recurrent glioblastoma

F Schmidt et al. Neurology. .

Abstract

The authors administered procarbazine, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU, lomustine), and vincristine (PCV) to 86 patients with recurrent glioblastoma. There were three partial responses, but no complete responses. Median progression-free survival was 17.1 weeks and progression-free survival at 6 months was 38.4%. World Health Organization grade III/IV hematologic toxicity was common (25.6%), but nonhematologic toxicity was mild.

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