Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2006 Feb 28;66(4):602-4.
doi: 10.1212/01.WNL.0000198762.41312.E1.

Effects of a gamma-secretase inhibitor in a randomized study of patients with Alzheimer disease

E R Siemers  1 , J F Quinn, J Kaye, M R Farlow, A Porsteinsson, P Tariot, P Zoulnouni, J E Galvin, D M Holtzman, D S Knopman, J Satterwhite, C Gonzales, R A Dean, P C May
Affiliations
Randomized Controlled Trial

Effects of a gamma-secretase inhibitor in a randomized study of patients with Alzheimer disease

E R Siemers et al. Neurology. .

Abstract

LY450139 dihydrate, a gamma-secretase inhibitor, was studied in a randomized, controlled trial of 70 patients with Alzheimer disease. Subjects were given 30 mg for 1 week followed by 40 mg for 5 weeks. Treatment was well tolerated. Abeta(1-40) in plasma decreased by 38.2%; in CSF, Abeta(1-40) decreased by 4.42 +/- 9.55% (p = not significant). Higher drug doses may result in additional decreases in plasma Abeta concentrations and a measurable decrease in CSF Abeta.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

MeSH terms

Substances

LinkOut - more resources