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Randomized Controlled Trial
. 2006 Feb 28;66(4):602-4.
doi: 10.1212/01.WNL.0000198762.41312.E1.

Effects of a gamma-secretase inhibitor in a randomized study of patients with Alzheimer disease

E R Siemers  1 , J F Quinn, J Kaye, M R Farlow, A Porsteinsson, P Tariot, P Zoulnouni, J E Galvin, D M Holtzman, D S Knopman, J Satterwhite, C Gonzales, R A Dean, P C May
Affiliations
Randomized Controlled Trial

Effects of a gamma-secretase inhibitor in a randomized study of patients with Alzheimer disease

E R Siemers et al. Neurology. .

Abstract

LY450139 dihydrate, a gamma-secretase inhibitor, was studied in a randomized, controlled trial of 70 patients with Alzheimer disease. Subjects were given 30 mg for 1 week followed by 40 mg for 5 weeks. Treatment was well tolerated. Abeta(1-40) in plasma decreased by 38.2%; in CSF, Abeta(1-40) decreased by 4.42 +/- 9.55% (p = not significant). Higher drug doses may result in additional decreases in plasma Abeta concentrations and a measurable decrease in CSF Abeta.

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