doi: 10.1038/ja.2005.109.
The biosynthetic gene cluster for the beta-lactam antibiotic tabtoxin in Pseudomonas syringae
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- PMID: 16506699
- DOI: 10.1038/ja.2005.109
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The biosynthetic gene cluster for the beta-lactam antibiotic tabtoxin in Pseudomonas syringae
J Antibiot (Tokyo).
2005 Dec.
Abstract
DNA sequence analysis revealed that the biosynthetic genes of the unusual beta-lactam antibiotic tabtoxin reside at the att site adjacent to the lysC tRNA gene in Pseudomonas syringae BR2. ORFs encoded within the region included ones with similarity to beta-lactam synthase and clavaminic acid synthase, as well as amino acid synthesis enzymes. Novel ORFs were present in a portion of the biosynthetic region associated with a toxin hypersensitivity phenotype. Tabtoxin resistance was associated with a fragment containing a major facilitator superfamily (MFS) transporter gene.
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