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Multicenter Study
. 2006 Mar;52(3):511-4.
doi: 10.1373/clinchem.2005.058537.

Polymorphisms in the interleukin-1 gene cluster in children and young adults with systemic meningococcemia

Georg Endler  1 , Rodrig Marculescu, Philipp Starkl, Alexander Binder, Gotho Geishofer, Martin Müller, Bettina Zöhrer, Bernhard Resch, Werner Zenz, Christine Mannhalter; Central European Meningococcal Genetic Study Group
Affiliations
Multicenter Study

Polymorphisms in the interleukin-1 gene cluster in children and young adults with systemic meningococcemia

Georg Endler et al. Clin Chem. 2006 Mar.

Abstract

Background: An association has been described between mortality in children with meningococcal disease and functional polymorphisms in the interleukin-1 (IL1) cluster. We undertook a multicenter study to evaluate associations of these polymorphisms in a Central European population.

Patients and methods: The study involved 95 Middle European pediatric hospitals. We collected blood samples from, and clinical information about, 285 previously healthy children with meningococcal infection. We used a newly developed multiplexed mutagenic separated PCR assay to analyze 6 polymorphisms within the IL1 cluster: IL1A (-889)C/T, IL1A (+4845)G/T, IL1B (-511)C/T, IL1B (-31)C/T, IL1B (+3954), and IL1RA (+2018)C/T. We studied the same polymorphisms in a comparison group of 481 healthy newborns.

Results: Genotype frequencies between patients and the comparison group differed significantly only for the IL1RA (+2018)C/T variant: The CC genotype was more frequent in patients (11%) than in healthy controls (5%; P = 0.008). In the patient group, the C allele was significantly more prevalent (67%) in nonsurvivors than in survivors (42%; P = 0.02).

Conclusion: The IL1RA (+2018)C/T polymorphism is associated with the risk of meningococcal disease and with its outcome.

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