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Clinical Trial
. 2006 Jan 9;20(2):294-7.
doi: 10.1097/01.aids.0000199819.40079.e9.

A randomized, placebo-controlled phase I trial of DNA prime, recombinant fowlpox virus boost prophylactic vaccine for HIV-1

Anthony D Kelleher, Rebekah L Puls, Mark Bebbington, David Boyle, Rosemary Ffrench, Stephen J Kent, Sue Kippax, Damian F J Purcell, Scott Thomson, Handan Wand, David A Cooper, Sean Emery
Clinical Trial

A randomized, placebo-controlled phase I trial of DNA prime, recombinant fowlpox virus boost prophylactic vaccine for HIV-1

Anthony D Kelleher et al. AIDS. .

Abstract

An HIV-vaccine consisting of a DNA prime, recombinant fowlpox virus (rFPV) boost was evaluated in a double-blind placebo controlled trial. One milligram of pHIS-HIV-B expressing mutated gag, pol, env, vpu, tat and rev was administered at weeks 0 and 4 boosted by 5 x 10(7) pfu rFPV-HIV-B expressing gag/pol at week 8. The vaccine regimen was safe, but there was no difference between vaccine (n = 18) and placebo recipients (n = 6) for Gag or Pol-specific T-cell immune responses at week 9.

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