Antigenic relationships of common rhinovirus types from disabling upper respiratory illnesses
- PMID: 165120
Antigenic relationships of common rhinovirus types from disabling upper respiratory illnesses
Abstract
The frequency of the common cold has been though to be due to the existence of more than 89 different serologic types of rhinoviruses. However, in the civilian and military population studied in this area from 1962 through 1970, types 1A, 1B, 2, 23, 29, 30 and 31 accounted for 81 percent of 487 rhinoviruses isolated from individuals with respiratory illnesses. Antigenic relationships between these types and others have been demonstrated by neutralization in WI-38 cell cultures and by immunodiffusion. Types 1A and 1b, 2 and 49, 23 and 30, 29 and 44 and others are related. With specific animal antisera, heterotypic antibody titers are minimal. However, following natural infection in man with one of these related types, antibody responses to the other was almost equal to the homotype and could predictably provide cross-protection. Even with inactive T13 rhinovirus vaccine in man, protective levels of neutralizing antibody to T41 were produced. It is clear that the rates of rhinovirus colds would be greatly increased if more than 89 immunologic distinct types actually existed. An effective vaccine could be easily prepared by selection of a few appropriate types, such as 1A, 2, 23, 29 and 31.
Similar articles
-
Circulating antibodies and respiratory virus infections.Dev Biol Stand. 1975;28:152-8. Dev Biol Stand. 1975. PMID: 165114
-
Broad antigenic relationships among rhinovirus serotypes revealed by cross-immunization of rabbits with different serotypes.J Immunol. 1975 Feb;114(2 Pt 1):635-9. J Immunol. 1975. PMID: 47360
-
Rhinoviruses: isolation from cattle with acute respiratory disease.Am J Vet Res. 1971 May;32(5):685-8. Am J Vet Res. 1971. PMID: 4325245 No abstract available.
-
An update on the pathophysiology of rhinovirus upper respiratory tract infections.Rhinology. 1999 Sep;37(3):97-103. Rhinology. 1999. PMID: 10567986 Review.
-
Antibody-mediated protection against respiratory viral infection.Semin Respir Crit Care Med. 2005 Dec;26(6):635-42. doi: 10.1055/s-2005-925527. Semin Respir Crit Care Med. 2005. PMID: 16388432 Review.
Cited by
-
Replication of rhinoviruses.Arch Virol. 1976;51(3):169-89. doi: 10.1007/BF01318022. Arch Virol. 1976. PMID: 61746 Review. No abstract available.
-
Antigenic groupings of 90 rhinovirus serotypes.Infect Immun. 1982 Aug;37(2):642-7. doi: 10.1128/iai.37.2.642-647.1982. Infect Immun. 1982. PMID: 6288568 Free PMC article.
-
Isolation of rhinovirus intertypes related to either rhinoviruses 12 and 78 or 36 and 58.Infect Immun. 1983 Apr;40(1):213-8. doi: 10.1128/iai.40.1.213-218.1983. Infect Immun. 1983. PMID: 6299958 Free PMC article.
-
The common cold.Prim Care. 1996 Dec;23(4):657-75. doi: 10.1016/s0095-4543(05)70355-9. Prim Care. 1996. PMID: 8890137 Free PMC article. Review.