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. 2006 Jul;35(7):649-52.
doi: 10.1016/j.ijom.2006.01.011. Epub 2006 Feb 28.

Induction of apoptosis by paclitaxel in human oral carcinoma cells

M Nonaka  1 , H Ikeda, A Fujisawa, M Uehara, T Inokuchi
Affiliations

Induction of apoptosis by paclitaxel in human oral carcinoma cells

M Nonaka et al. Int J Oral Maxillofac Surg. 2006 Jul.

Abstract

The present study investigated induction of apoptosis in NB-1 oral carcinoma cells by paclitaxel and the expression of Bcl-2 and Bax in relation to this apoptotic cell death. Paclitaxel induced apoptotic cell death in NB-1 cells in a dose- and a time-dependent manner. The present results suggest that paclitaxel can induce apoptosis of NB-1 cells, which may be mediated by down-regulation of Bcl-2 together with up-regulation of Bax.

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