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Review
. 2006 Apr;22(4):232-40.
doi: 10.1016/j.tig.2006.02.009. Epub 2006 Mar 2.

Rat genetics: the next episode

Bart M G Smits  1 , Edwin Cuppen
Affiliations
Review

Rat genetics: the next episode

Bart M G Smits et al. Trends Genet. 2006 Apr.

Abstract

More than a thousand quantitative trait loci (QTLs) relevant to many aspects of complex human disease have been identified in a wide range of rat inbred lines over the past few decades. With the complete rat genome available, it is now time for the next stage in rat genetic research: the identification and causal confirmation of underlying polymorphisms and genes. Recent developments in single nucleotide polymorphism-based genetic markers and technologies to manipulate the rat genome will undoubtedly be important tools in this next episode.

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