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. 2006 Dec;129(2):145-9.
doi: 10.1016/j.ejogrb.2005.12.029. Epub 2006 Mar 6.

Electrical impedance spectroscopy of the cervix in non-pregnant and pregnant women

Saurabh V Gandhi  1 , Dawn Walker, Pete Milnes, Soma Mukherjee, Brian H Brown, Dilly O C Anumba
Affiliations

Electrical impedance spectroscopy of the cervix in non-pregnant and pregnant women

Saurabh V Gandhi et al. Eur J Obstet Gynecol Reprod Biol. 2006 Dec.

Abstract

Objectives: We sought to validate and measure the electrical impedance of the uterine cervix in non-pregnant and pregnant women by spectroscopy.

Study design: Cervical stromal impedance (CSI) was measured in 50 non-pregnant, 20 1st, 20 2nd and 50 3rd trimester pregnant women. The technique was also validated by comparing in vivo data to a finite element (FE) model of cervical tissue.

Results: CSI agreed well with the FE model and was highly reproducible in all study groups. Mean (S.E.) CSI at 4-819 kHz was higher in pregnant (2.78 +/- 0.09 Omega m) compared to non-pregnant (2.38 +/- 0.07, p < 0.01) women, and in the 3rd trimester (3.08 +/- 0.13) compared to non-pregnant (p < 0.01), 1st trimester (2.42 +/- 0.12, p < 0.001) and 2nd trimester (2.20 +/- 0.05, p < 0.001) pregnant women.

Conclusion: Measurement of CSI provides a non-invasive method of assessing cervical tissue characteristics. Cervical extracellular matrix synthesis and leukocyte infiltration may account for the increased tissue impedance noted in the 3rd trimester.

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